Predictions of primate–parasite coextinctionĬharlie Nunn worked with Duke professors James Herrera and James Moody to analyze potential effects on parasite existence and biodiversity if primates threatened with extinction go extinct. This is the largest study of bevacizumab toxicity and it provides new markers of drug safety for further evaluation. Kouros Owzar was part of a team that conducted a GWAS meta-analysis on 1039 patients of European ancestry who have been treated with bevacizumab, a medication used to treat a number of types of cancers.
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Read the news release on Eureka Alerts Read full text in Natureīevacizumab-induced hypertension and proteinuria: a genome-wide study of 1000+ patients Ru-Rong Ji and colleagues surveyed the "junkyard of cancer drugs" that might have the potential to be repurposed to aid in chronic pain and discovered that kenpaullone and similarly-acting kinase-inhibitory compounds, as well as delta-CAT gene therapy, have the potential to become new tools in our toolbox against chronic refractory pain, including nerve injury pain and cancer bone pain, and likely against other forms of chronic pain. Repurposing cancer drugs identifies kenpaullone which ameliorates pathologic pain in preclinical models via normalization of inhibitory neurotransmission Yongmei Liu and colleagues used the Multi-Ethnic Study of Atherosclerosis (MESA) cohort to examine the role of DNA methylation on the association between physical activity and cardiovascular disease. Role of DNA methylation on the association between physical activity and cardiovascular diseases: Results from the longitudinal multi-ethnic study of atherosclerosis (MESA) cohort They identified a homozygous segregating variant in the gene encoding clavesin-1 in a family with three affected individuals. Rasheed Gbadegesin, Gentzon Hall, Alejandro Ochoa and colleagues performed next generation sequencing in patients with familiar steroid sensitive nephrotic syndrome, a common pediatric kidney disease that is responsive to steroids. Steroid-sensitive nephrotic syndrome candidate gene CLVS1 regulates podocyte oxidative stress and endocytosis Read full text in Nature Neuroscience Read article in Duke Today By swiftly discerning the precise identity of nutrient stimuli, gut neuropod cells serve as the entry point to guide nutritive choices. They showed that preference for sugar over sweetener in mice depends on neuropod cell glutamatergic signaling. The preference for sugar over sweetener depends on a gut sensor cellĭiego Bohorquez and colleagues discovered that cholecystokinin (CCK)-labeled duodenal neuropod cells can tell the difference between sugars and artificial sweeteners. Read full text in Nature Chemical Biology Their results reveal a general mechanism underlying the maintenance of microbial diversity and have implications for natural and engineered communities. Lingchong You, Lawrence David and team investigated spatial partitioning of microbial communities and its effects on biodiversity. Modulation of microbial community dynamics by spatial partitioning Serum metabolomic analysis of men on a low-carbohydrate diet for biochemically recurrent prostate cancer reveals the potential role of ketogenesis to slow tumor growth: A secondary analysis of the CAPS2 diet trialĪshley Chi and colleagues investigated the effect a low-carbohydrate diet had on prostate cancer growth using both animal models and participants in the Carbohydrate and Prostate Study 2 (CAPS2) clinical study.
Nenad Bursac, Yarui Diao and colleagues investigated the specific roles that muscle fibers, a critical niche constituent, have in human satellite cell maintenance and injury-induced activation by utilizing human myobundles made from purified myogenic cells. Myoblast deactivation within engineered human skeletal muscle creates a transcriptionally heterogeneous population of quiescent satellite-like cells Read full text in Frontiers in Physiology Their results show new insights into gene expression regulation and heterogeneity among red blood cells. Single Cell RNA-Seq Analysis of Human Red CellsĪshley Chi, Simon Gregory and team performed single red cell RNA-seq of circulating red blood cells from three healthy donors that had been storied for one or 15 days and found that the expression pattern of single red blood cells separates into distinct cellular clusters. Summer Undergraduate Research Opportunities.Duke Research and Discovery COVID-19 Response.
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